Most megacolon cases are medically treated although surgery is often performed. A colectomy will remove as much of the colon that gets rid of the anatomy that was causing the problem in the first place. The big problem with this is the production of soft, frequent stools.
Medical therapy is geared to making feces easier to pass. This can be accomplished by dietary change to a food higher in roughage. Metamucil® can be added daily to the food. Lactulose may also be prescribed to loosen up stools in the colon by increased water absorption into the colon.
In severe cases, animals are extremely ill and need to be hospitalized. They are sedated and the lower bowel is manual emptied or flushed with enemas. Intravenous fluids are always given since most cats are severely dehydrated making colonic peristalsis even worse due to dehydration at the intestinal level. Antibiotics and other support care are administered.